| The free form of insulin-like growth factor I increases in circulation during normal human pregnancy. | |
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MedLine Citation:
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PMID: 7593439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The main circulating insulin-like growth factor-binding protein (IGFBP) in human, IGFBP-3, markedly decreases during pregnancy, as determined by Western ligand blotting, and its decrease is due to an endogenous pregnancy-related serum IGFBP-3 proteolytic activity. Proteolysis of IGFBP-3 may result in the free form of IGF-I (fIGF-I) being liberated from or weakly bound to IGFBP-3 fragments. The purpose of this study was to determine the plasma concentration of fIGF-I and the mechanism of fIGF-I regulation during normal human pregnancy. We studied 19 normal pregnant women at 6-8 weeks gestation, 24 normal pregnant women at 28-30 weeks gestation, and 25 nonpregnant women. We measured plasma fIGF-I using a recently established immunoradiometric assay. We also measured plasma total IGF-I (free plus complexed forms of IGF-I) using immunoradiometric assay, and IGFBP-3 proteolytic activity using a IGFBP-3 protease assay. fIGF-I levels at 6-8 weeks gestation (4.11 +/- 0.23 ng/mL) and at 28-30 weeks gestation (3.67 +/- 0.21 ng/mL) were significantly higher than that in nonpregnant women (2.48 +/- 0.12 ng/mL; P < 0.001 in both). Total IGF-I levels at 6-8 weeks gestation (168.0 +/- 9.1 ng/mL) and at 28-30 weeks gestation (241.5 +/- 19.0 ng/mL) were significantly lower than that in nonpregnant women (283.9 +/- 12.3 ng/mL; P < 0.001 at 6-8 weeks gestation and P < 0.05 at 28-30 weeks gestation). All pregnant serum studied had IGFBP-3 proteolytic activity. These data indicate that during normal human pregnancy, circulatory fIGF-I increases, probably due to IGFBP-3 proteolytic activity. |
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Authors:
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T Hasegawa; Y Hasegawa; M Takada; Y Tsuchiya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 80 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-12-28 Completed Date: 1995-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3284-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology and Metabolism, Tokyo Metropolitan Kiyose Children's Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Insulin-Like Growth Factor Binding Protein 3 / metabolism Insulin-Like Growth Factor I / metabolism* Osmolar Concentration Peptide Hydrolases / metabolism Pregnancy / blood* Pregnancy Trimester, First Pregnancy Trimester, Second Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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