| A free-breathing non-contrast-enhanced pulmonary magnetic resonance angiography at 3 Tesla. | |
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MedLine Citation:
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PMID: 19781294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The breathhold contrast-enhanced three-dimensional magnetic resonance angiography (MRA) using T1-weighted gradient-echo imaging sequence is the standard technique for MRA of the thorax. However, this technique is not desirable for certain patients with respiratory insufficiency, serious renal impairment, or allergy to contrast agents. The objective of this study was to optimize and evaluate a non-contrast-enhanced free-breathing pulmonary MRA protocol at 3 Tesla. METHODS: The time-of-flight protocol was based on a two-dimensional T1-weighted turbo field echo sequence with slice-selective inversion recovery and magnetization transfer preparation together with respiratory navigator gating, cardiac gating, and parallel imaging. Optimal values for time of inversion delay, flip angle and slice thickness were experimentally determined and used for all subjects. RESULTS: Excellent pulmonary MRA images, in which the 7th order branches of pulmonary arteries could be reliably identified, were obtained in the 12 free-breathing healthy volunteers. TI of approximately 300 ms provides the best suppression of background thoracic and cardiac muscles and effective inflow enhancement. With increasing flip angle, the pulmonary vessels gradually brightened and exhibited optimal contrast at 20 degrees-30 degrees. The 2 mm slice thickness and 0.5 mm slice overlap is suitable for visualization of the peripheral pulmonary vessel. CONCLUSIONS: The MRA protocol at 3 Tesla may have clinical significance for pulmonary vascular imaging in patients who are not available for contrast-enhanced 3D MRA and CT angiography examination or are unable to sustain a long breath-hold. |
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Authors:
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Jian Yang; Wei Wang; Ya-rong Wang; Gang Niu; Chen-wang Jin; Ed Xuekui Wu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese medical journal Volume: 122 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 2111-6 Citation Subset: IM |
Affiliation:
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Medical Imaging Center, First Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. yj1118@mail.xjtu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Contrast Media* Female Humans Magnetic Resonance Angiography / methods* Male Middle Aged Pulmonary Artery / anatomy & histology Pulmonary Circulation / physiology Pulmonary Veins / anatomy & histology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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