Document Detail

A framework for strategic investments in research to reduce the global burden of preterm birth.
MedLine Citation:
PMID:  22999156     Owner:  NLM     Status:  MEDLINE    
Preterm birth and stillbirth are among the greatest health burdens associated with pregnancy and childbirth. Fifteen million babies are born preterm each year, causing about 1 million deaths annually and lifelong problems for many survivors; 3 million stillbirths also occur annually. Worldwide, the number of women and children who die during pregnancy and childbirth exceeds the total number of births in the United States. New approaches could provide a greater understanding of prematurity, stillbirth, and maternal complications of pregnancy and childbirth. Integrated multidisciplinary investigations of the mother, fetus, and newborn in different contexts and populations could elucidate the biological pathways that result in adverse outcomes and how to prevent them. Descriptive research can determine the burden of disease, while more mechanistic discovery research could explore the physiology and pathophysiology of pregnancy and childbirth. Together, this research can lead to the development and delivery of new and much more effective interventions, even in low-resource settings. Recent surveys of researchers and funders reveal a striking lack of consensus regarding priority areas for research and the development of interventions. While researchers enumerate unanswered questions about pregnancy and childbirth, they lack consensus on priorities. Funders are equally uncertain about research and development projects that need to be undertaken, and many are hard-pressed to support research on the complex problems of pregnancy and childbirth given competing priorities. This lack of consensus provides an opportunity to engage with funders and researchers to recognize the importance of understanding healthy pregnancies and the consequences of adverse pregnancy outcomes. A strategic alliance of funders, researchers, nongovernmental organizations, the private sector, and others could organize a set of grand challenges centered on pregnancy and childbirth that could yield a substantial improvement in reproductive health.
Michael G Gravett; Craig E Rubens;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-10
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-01-22     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children's, Seattle, WA, USA.
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MeSH Terms
Biomedical Research / economics*,  organization & administration
Fetal Diseases / economics,  prevention & control
Pregnancy Complications / economics,  prevention & control
Premature Birth / economics*,  prevention & control
Prenatal Care / economics,  organization & administration
Stillbirth / economics
Comment In:
Am J Obstet Gynecol. 2013 Jun;208(6):508-9   [PMID:  23352989 ]
Am J Obstet Gynecol. 2012 Nov;207(5):343-4   [PMID:  23107077 ]
Am J Obstet Gynecol. 2013 Jun;208(6):508   [PMID:  23352987 ]

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