Document Detail


A framework for the in vivo pathomechanics of osteoarthritis at the knee.
MedLine Citation:
PMID:  15095819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vivo pathomechanics of osteoarthritis (OA) at the knee is described in a framework that is based on an analysis of studies describing assays of biomarkers, cartilage morphology, and human function (gait analysis). The framework is divided into an Initiation Phase and a Progression Phase. The Initiation Phase is associated with kinematic changes that shift load bearing to infrequently loaded regions of the cartilage that cannot accommodate the loads. The Progression Phase is defined following cartilage breakdown. During the Progression Phase, the disease progresses more rapidly with increased load. While this framework was developed from an analysis of in vivo pathomechanics, it also explains how the convergence of biological, morphological, and neuromuscular changes to the musculoskeletal system during aging or during menopause lead to the increased rate of idiopathic OA with aging. Understanding the in vivo response of articular cartilage to its physical environment requires an integrated view of the problem that considers functional, anatomical, and biological interactions. The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee.
Authors:
Thomas P Andriacchi; Anne Mündermann; R Lane Smith; Eugene J Alexander; Chris O Dyrby; Seungbum Koo
Related Documents :
19047719 - The geometry of the tibial plateau and its influence on the biomechanics of the tibiofe...
1729969 - Osteoarthritis of the knee: effects on gait, strength, and flexibility.
3855729 - Skeletal changes in dentists and farmers in finland.
21454389 - Sex differences in cognitive domains and their clinical correlates in higher-functionin...
8893429 - Growth of the cervical spine with special reference to its lordosis and mobility.
21194109 - Abundance of antennal chemosensilla in two parasitoid wasps with different degree of ho...
23940839 - How age influences phonotaxis in virgin female jamaican field crickets (gryllus assimil...
14571809 - Etiology of acute pancreatitis--a multi-center study in taiwan.
23147059 - The chest and aging: radiological findings.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  32     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-20     Completed Date:  2004-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-57     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305-4038, USA. tandriac@stanford.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Biomechanics / methods
Cartilage, Articular / pathology,  physiopathology*
Chondrocytes*
Disease Progression
Gait*
Humans
Knee Joint / pathology,  physiopathology
Mechanotransduction, Cellular*
Models, Biological*
Osteoarthritis, Knee / pathology,  physiopathology*
Weight-Bearing*
Grant Support
ID/Acronym/Agency:
AR045788/AR/NIAMS NIH HHS; AR049792/AR/NIAMS NIH HHS; AR39421/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Integrin-dependent signal cascades in chondrocyte mechanotransduction.
Next Document:  New perspectives on bioengineering of joint tissues: joint adaptation creates a moving target for en...