Document Detail

A framework for the in vivo pathomechanics of osteoarthritis at the knee.
MedLine Citation:
PMID:  15095819     Owner:  NLM     Status:  MEDLINE    
The in vivo pathomechanics of osteoarthritis (OA) at the knee is described in a framework that is based on an analysis of studies describing assays of biomarkers, cartilage morphology, and human function (gait analysis). The framework is divided into an Initiation Phase and a Progression Phase. The Initiation Phase is associated with kinematic changes that shift load bearing to infrequently loaded regions of the cartilage that cannot accommodate the loads. The Progression Phase is defined following cartilage breakdown. During the Progression Phase, the disease progresses more rapidly with increased load. While this framework was developed from an analysis of in vivo pathomechanics, it also explains how the convergence of biological, morphological, and neuromuscular changes to the musculoskeletal system during aging or during menopause lead to the increased rate of idiopathic OA with aging. Understanding the in vivo response of articular cartilage to its physical environment requires an integrated view of the problem that considers functional, anatomical, and biological interactions. The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee.
Thomas P Andriacchi; Anne Mündermann; R Lane Smith; Eugene J Alexander; Chris O Dyrby; Seungbum Koo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  32     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-20     Completed Date:  2004-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-57     Citation Subset:  IM    
Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305-4038, USA.
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MeSH Terms
Biomechanics / methods
Cartilage, Articular / pathology,  physiopathology*
Disease Progression
Knee Joint / pathology,  physiopathology
Mechanotransduction, Cellular*
Models, Biological*
Osteoarthritis, Knee / pathology,  physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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