| A frame shifted disulfide bridged analogue of angiotensin II. | |
MedLine Citation:
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PMID: 12614883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-(2-Mercaptoethyl)glycine [NMGly] was incorporated into the 3 and 5 positions of angiotensin II and oxidized to give the corresponding cyclized disulfide c[NMGly(3,5)]Ang II. The binding affinity to the angiotensin II receptor (AT(1)) of this conformationally constrained analogue, which is related to the potent Ang II agonist c[Hcy(3,5)]Ang II, was examined. The analogue had no affinity to the AT(1) receptor. Theoretical conformational analysis was performed to compare the conformational characteristics of model compounds of c[Hcy(3,5)]Ang II and the frame shifted analogue c[NMGly(3,5)]Ang II in an attempt to explain the lack of affinity. |
Authors:
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Boris Schmidt; Christian Kühn; Dennis K Ehlert; Gunnar Lindeberg; Susanna Lindman; Anders Karlén; Anders Hallberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 11 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-04 Completed Date: 2003-11-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 985-90 Citation Subset: IM |
Affiliation:
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TU Darmstadt, Institut for Organic Chemistry, Petersenstr. 22, D-64287 Darmstadt, Germany. schimbo@oc.chemie.tu.darmstadt.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
/
analogs & derivatives*,
chemistry,
metabolism Animals CHO Cells Cell Division / drug effects Chemistry, Physical Cricetinae Disulfides / chemistry* Indicators and Reagents Peptides / chemical synthesis Physicochemical Phenomena Protein Conformation Radioligand Assay Rats Receptor, Angiotensin, Type 1 / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Disulfides; 0/Indicators and Reagents; 0/Peptides; 0/Receptor, Angiotensin, Type 1; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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