Document Detail

A fraction of deep vascular birthmarks are true deep hemangiomas of infancy.
MedLine Citation:
PMID:  19659859     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Deeply-located vascular birthmarks have been traditionally regarded as being identical to a deep type of hemangioma of infancy (HOI). However, there is increasing evidence that some venous malformations also mimic these deep type of HOIs clinically. This study investigates how many, if not all, deep vascular birthmarks are deep type HOIs. METHODS: Nineteen cases were selected on the basis of the clinical features of deeply-located vascular birthmarks. Hematoxylin-eosin slides were reviewed and immunohistochemistries were performed using CD31, D2-40 and GLUT1 to confirm diagnoses before they were compared with the clinicoradiologic review by specialists other than dermatopathologists. RESULTS: Only 4 patients out of a total of 19 cases were strongly positive for GLUT1 staining and turned out to be true deep HOIs. The remaining were comprised of 6 venous malformations (31.6%), 3 lymphatic malformations (15.8%), 1 glomangioma (5.3%) and 5 tufted angiomas (26.3%). CONCLUSION: It was demonstrated that all deeply-located vascular birthmarks are not true deep HOIs. It is recommended that diagnosis for HOI be carried out cautiously earlier in life using GLUT1 in addition to clinical features. This would help prevent patients from being misled by anticipating the spontaneous involution in all deeply-located vascular birthmarks.
Seok-Jong Lee; Dong Ju Shin; Ho Youn Kim; Weon Ju Lee; Do Won Kim; Ho Yun Chung; Seung Kug Baik; Jong Min Lee; Seung Huh; Ghil Suk Yoon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of dermatology     Volume:  48     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-07     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  817-21     Citation Subset:  IM    
Department of Dermatology, Vascular Anomalies Clinic, Kyungpook National University School of Medicine, Daegu, South Korea.
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MeSH Terms
Antibodies, Monoclonal
Antigens, CD31 / metabolism
Child, Preschool
Glucose Transporter Type 1 / metabolism
Hemangioma / metabolism,  pathology*
Lymphatic System / abnormalities
Skin / blood supply*,  pathology*
Tumor Markers, Biological
Vascular Malformations / metabolism,  pathology*
Vascular Neoplasms / metabolism,  pathology*
Veins / abnormalities
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD31; 0/Glucose Transporter Type 1; 0/SLC2A1 protein, human; 0/Tumor Markers, Biological; 0/monoclonal antibody D2-40

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