| A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. | |
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MedLine Citation:
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PMID: 3783014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two systems for measuring embryo development in vitro were evaluated. One was a 1-4 scale based on a subjective evaluation of embryo quality (EQ) from microscopic appearance. In addition, a formula for scoring embryo growth rate in vitro was developed. The embryo development rating (EDR) was based on the ratio between the time at which embryos were observed at a particular stage after insemination and the time at which they would be expected to reach that stage in a hypothetical "ideal" growth rate with a cell cycle length of 11.9 hr. Using this scoring system, "normally" growing embryos scored 100. This approach was aimed at partially normalizing the data and allowed all embryos to be analyzed similarly regardless of the time of observation. Analysis of 1539 embryo replacements resulting in 232 clinical pregnancies showed that both EDR and embryo-quality scores were of value in predicting success, with clinical pregnancy most likely to eventuate from a combination of moderate to good EQ scores (2-4) coupled with average or above-average growth rates (EDR scores from 90 to 129). Poor-quality and very slowly or very rapidly growing embryos were underrepresented in cycles that proceeded to pregnancy. These inferences were based on all embryos transferred (mean, 2.73 per transfer cycle), and they were substantiated by an analysis of 33 pregnancies resulting from replacement of a single embryo and from 18 pregnancies in which all embryos scored the same with both systems. EQ and EDR were significantly associated with each other and together provide a valuable guide in predicting pregnancy, in selecting embryos for freezing, and in monitoring day-to-day performance in the in vitro fertilization (IVF) program. |
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Authors:
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J M Cummins; T M Breen; K L Harrison; J M Shaw; L M Wilson; J F Hennessey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of in vitro fertilization and embryo transfer : IVF Volume: 3 ISSN: 0740-7769 ISO Abbreviation: J In Vitro Fert Embryo Transf Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1987-01-13 Completed Date: 1987-01-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8412594 Medline TA: J In Vitro Fert Embryo Transf Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 284-95 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Embryo Transfer Embryo, Mammalian / physiology* Embryonic and Fetal Development* Female Fertilization in Vitro* Follow-Up Studies Humans Male Oocytes / cytology Pregnancy Sperm-Ovum Interactions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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