| The formation of furfural compounds in selected saccharide- and polysaccharide-based pharmaceutical excipients. | |
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MedLine Citation:
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PMID: 22318787 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The acid hydrolysis of various selected saccharide- and polysaccharide-based pharmaceutical excipients under acid hydrolysis and the formation of degradation compounds were studied. New degradation products formed from these excipients were discovered. Liquid chromatography-mass spectrometry and nuclear magnetic resonance techniques were employed to identify and fully characterize these unknown compounds. The degradation products were identified as [(5-formylfuran-2-yl)methoxy]acetic acid, 5-[(propan-2-yloxy)methyl]furan-2-carbaldehyde, along with the previously identified 5-(methoxymethyl)furan-2-carbaldehyde. On the basis of the identification of these degradation products, a reasonable mechanism for their formation can be proposed. Temperature and pH affect the hydrolysis rates of saccharides and polysaccharides, which in turn affects the rate of formation of furfural compounds. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci. |
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Authors:
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Michal Douša; Petr Gibala; Jiří Břicháč; Jaroslav Havlíček |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-8 |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: - ISSN: 1520-6017 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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ZENTIVA, a.s. Praha, 102 37 Prague 10, Czech Republic. michal.dousa@seznam.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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