| The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe. | |
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MedLine Citation:
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PMID: 15302827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In eukaryotes the regulation of gene expression plays a key role in controlling cell cycle progression. Here, we demonstrate that a forkhead transcription factor, Fkh2, regulates the periodic expression of cdc15(+) and spo12(+) in the M and G(1) phases of the cell division cycle in the fission yeast Schizosaccharomyces pombe. We also show that Fkh2 is important for several cell cycle processes, including cell morphology and cell separation, nuclear structure and migration, and mitotic spindle function. We find that the expression of fkh2(+) is itself regulated in a cell cycle-dependent manner in G(1) coincident with the expression of cdc18(+), a Cdc10-regulated gene. However, fkh2(+) expression is independent of Cdc10 function. Fkh2 was found to be phosphorylated during the cell division cycle, with a timing that suggests that this posttranslational modification is important for cdc15(+) and spo12(+) expression. Related forkhead proteins regulate G(2) and M phase-specific gene expression in the evolutionarily distant Saccharomyces cerevisiae, suggesting that these proteins play conserved roles in regulating cell cycle processes in eukaryotes. |
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Authors:
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Richard Bulmer; Aline Pic-Taylor; Simon K Whitehall; Kate A Martin; Jonathan B A Millar; Janet Quinn; Brian A Morgan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Eukaryotic cell Volume: 3 ISSN: 1535-9778 ISO Abbreviation: Eukaryotic Cell Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-10 Completed Date: 2005-09-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101130731 Medline TA: Eukaryot Cell Country: United States |
Other Details:
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Languages: eng Pagination: 944-54 Citation Subset: IM |
Affiliation:
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Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Cell Cycle / physiology* Cell Cycle Proteins / genetics, metabolism Fungal Proteins / genetics, metabolism GTP Phosphohydrolases GTP-Binding Proteins / genetics, metabolism Gene Expression Regulation, Fungal* Membrane Proteins Molecular Sequence Data Saccharomyces cerevisiae Proteins Schizosaccharomyces / cytology, physiology* Schizosaccharomyces pombe Proteins / chemistry, genetics, metabolism* Sequence Alignment Transcription Factors / chemistry, genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/CDC15 protein; 0/Cell Cycle Proteins; 0/Fkh2 protein, S pombe; 0/Fungal Proteins; 0/Membrane Proteins; 0/Saccharomyces cerevisiae Proteins; 0/Schizosaccharomyces pombe Proteins; 0/Transcription Factors; 0/cdc10 protein, S pombe; 0/spo12 protein, S pombe; EC 3.6.1.-/CDC10 protein, S cerevisiae; EC 3.6.1.-/GTP Phosphohydrolases; EC 3.6.1.-/GTP-Binding Proteins |
| Comments/Corrections | |
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