Document Detail


A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions.
MedLine Citation:
PMID:  21945724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cues associated with rewards acquire the ability to engage the same brain systems as rewards themselves. However, reward cues have multiple properties. For example, they not only act as predictors of reward capable of evoking conditional responses (CRs), but they may also acquire incentive motivational properties. As incentive stimuli they can evoke complex emotional and motivational states. Here we sought to determine whether the predictive value of a reward cue is sufficient to engage brain reward systems, or whether the cue must also be attributed with incentive salience. We took advantage of the fact that there are large individual differences in the extent to which reward cues are attributed with incentive salience. When a cue (conditional stimulus, CS) is paired with delivery of food (unconditional stimulus, US), the cue acquires the ability to evoke a CR in all rats; that is, it is equally predictive and supports learning the CS-US association in all. However, only in a subset of rats is the cue attributed with incentive salience, becoming an attractive and desirable incentive stimulus. We used in situ hybridization histochemistry to quantify the ability of a food cue to induce c-fos mRNA expression in rats that varied in the extent to which they attributed incentive salience to the cue. We found that a food cue induced c-fos mRNA in the orbitofrontal cortex, striatum (caudate and nucleus accumbens), thalamus (paraventricular, intermediodorsal and central medial nuclei), and lateral habenula, only in rats that attributed incentive salience to the cue. Furthermore, patterns of "connectivity" between these brain regions differed markedly between rats that did or did not attribute incentive salience to the food cue. These data suggest that the predictive value of a reward cue is not sufficient to engage brain reward systems-the cue must also be attributed with incentive salience.
Authors:
S B Flagel; C M Cameron; K N Pickup; S J Watson; H Akil; T E Robinson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-10
Journal Detail:
Title:  Neuroscience     Volume:  196     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-02-23     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-96     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism,  physiology
Cerebral Cortex / metabolism,  physiology*
Conditioning, Classical / physiology
Corpus Striatum / metabolism,  physiology*
Cues*
Food
In Situ Hybridization / methods
Individuality
Male
Motivation / physiology*
Neural Pathways / metabolism,  physiology
Proto-Oncogene Proteins c-fos / biosynthesis*
Rats
Rats, Sprague-Dawley
Reward
Thalamus / metabolism,  physiology*
Grant Support
ID/Acronym/Agency:
R37 DA004294/DA/NIDA NIH HHS; R37 DA004294-23/DA/NIDA NIH HHS; R37-DA04294/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos
Comments/Corrections

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