Document Detail


Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study.
MedLine Citation:
PMID:  22433379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to assess the value and reliability of serologic testing for predicting clinical food allergy in a population-based cohort of infants with atopic dermatitis (AD). Infants 3-18 months of age, recruited from the general population, were followed quarterly for 3 years and carefully evaluated for evidence of immediate reactions to foods. Specific serum IgE levels for six foods were assayed at 3-5 years. Parents were interviewed at each visit regarding past/current immediate food-specific reactions involving skin, gut or respiratory systems. Data were entered into Excel for calculations of performance characteristics. Nine of the 40 patients (23%) who completed 3 years of follow-up had reactions to one or more foods. Reactions occurred in 5, 11 and 18% to milk, peanut and egg ingestion, respectively. In contrast, 30% of food-specific serum IgE tests were above normal. Predictive reliability of tests was generally low unless values were in the high range for peanut and milk. Conversely, egg allergy could be seen across a nearly full-spectrum of IgE values, making prediction highly unreliable. We conclude that physician and patient misinterpretation of the relevance and reliability of allergy testing may misdirect proper prevention and therapy of AD.
Authors:
Laura E Keck; Eric L Simpson; Trista M Berry; Jon M Hanifin
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Publication Detail:
Type:  Journal Article     Date:  2012-03-13
Journal Detail:
Title:  Chemical immunology and allergy     Volume:  96     ISSN:  1662-2898     ISO Abbreviation:  Chem Immunol Allergy     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-21     Completed Date:  2012-07-27     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101183835     Medline TA:  Chem Immunol Allergy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Dermatitis, Atopic / immunology,  pathology*
Egg Hypersensitivity / immunology,  pathology
Follow-Up Studies
Food Hypersensitivity / immunology,  pathology*
Humans
Immunoglobulin E / blood
Infant
Interviews as Topic
Milk Hypersensitivity / immunology,  pathology
Peanut Hypersensitivity / immunology,  pathology
Grant Support
ID/Acronym/Agency:
K23 AR057486/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E
Comments/Corrections

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