| A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. | |
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MedLine Citation:
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PMID: 10866386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template. |
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Authors:
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T Owa; T Okauchi; K Yoshimatsu; N H Sugi; Y Ozawa; T Nagasu; N Koyanagi; T Okabe; K Kitoh; H Yoshino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 10 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-11-07 Completed Date: 2000-11-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1223-6 Citation Subset: IM |
Affiliation:
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Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan. t-owa@hhc.eisai.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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drug effects* Drug Screening Assays, Antitumor Humans Sulfonamides / chemistry*, pharmacology Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Sulfonamides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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