Document Detail


A focus on the human lens in vitro.
MedLine Citation:
PMID:  21783660     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are maintained, or disrupted leading to a loss of transparency, are likely to differ in some cases between animals and humans. To allow comparison to take place, human in vitro models have been developed, ranging from whole organ culture to the generation of human lens cell lines. All have their merits and limitations, but as a whole, they permit extensive studies of lens cell behaviour and function to be carried out. Together, these in vitro methods allow the biological events of the lens to be further understood. Moreover, they could help identify the mechanisms that give rise to cataract and posterior capsule opacification, a problem that occurs following surgery, providing therapeutic targets for their prevention.
Authors:
I Michael Wormstone; David J Collison; Simon P Hansom; George Duncan
Publication Detail:
Type:  Journal Article     Date:  2005-08-22
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  21     ISSN:  1382-6689     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2011-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  -    
Affiliation:
The Humane Research Trust, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
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