Document Detail

A fluorescent "turn-on" probe for the dual-channel detection of Hg(II) and Mg(II) and its application of imaging in living cells.
MedLine Citation:
PMID:  21872078     Owner:  NLM     Status:  In-Data-Review    
A novel rhodamine-based fluorescent chemosensor (RND) was synthesized that contains two independent fluorophores and acts as a very sensitive, selective and reversible off-on probe for Hg(II). Importantly, this newly developed sensing system exhibited different fluorescent responses toward Hg(II) and Mg(II) at 589nm and 523nm, respectively. RND also displayed detectable color change upon treatment with Hg(II). Results from confocal laser scanning microscopy experiments demonstrated that this chemosensor is cell permeable and can be used as a fluorescent probe for monitoring Hg(II) or Mg(II) in living cells. This probe can also indirectly detect glutathione (GSH) and cysteine (Cys) with good linear relationships.
Yan Zhao; Baozhan Zheng; Juan Du; Dan Xiao; Li Yang
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Publication Detail:
Type:  Journal Article     Date:  2011-07-27
Journal Detail:
Title:  Talanta     Volume:  85     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  2194-201     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
College of Chemistry, Sichuan University, Chengdu 610064, PR China.
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