| A fluorescence sensor for detection of geranyl pyrophosphate by the chemo-ensemble method. | |
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MedLine Citation:
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PMID: 19049370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hexaamide receptor 4 and coumarin phosphate 5 form an ensemble for effective sensing of geranyl pyrophosphate (GPP). Fluorescence resonance energy transfer in the 4 + 5 ensemble diminishes when 5 is replaced by GPP. Receptor 4 binds selectively with GPP over other anions, including fatty acids. The 4-GPP complex in 1:1 stoichiometry is inferred by NMR and fluorescence titrations. Receptor 4 contains a pseudotetrahedral cleft to accommodate GPP via multiple hydrogen bonds, and the two aliphatic chains exert additional hydrophobic interactions. |
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Authors:
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Kuan-Hung Chen; Jen-Hai Liao; Hsin-Yu Chan; Jim-Min Fang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 74 ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 895-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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chemistry Calibration Coumarins / chemistry Fluorescence Fluorescent Dyes / chemistry* Magnetic Resonance Spectroscopy Polyisoprenyl Phosphates / analysis* Titrimetry |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Coumarins; 0/Fluorescent Dyes; 0/Polyisoprenyl Phosphates; 763-10-0/geranyl pyrophosphate; 91-64-5/coumarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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