Document Detail


A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque.
MedLine Citation:
PMID:  21770037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix metalloproteinase (MMP)-2 and -9 play important roles in the progression of atherosclerosis. This study aims to determine whether MMP-2 and -9 content in the fibrotic caps of atherosclerotic plaque is correlated with plaque autofluorescence. A time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) system was used to measure the autofluorescence and assess the biochemical composition of human plaques obtained from carotid endarterectomy. Results presented here demonstrate for the first time the ability to characterize the biochemical composition as it relates to MMP-2 and -9 content in the atherosclerotic plaque cap using a label-free imaging technique implemented with a fiberoptic TR-LIFS system.
Authors:
Jennifer E Phipps; Nisa Hatami; Zorina S Galis; J Dennis Baker; Michael C Fishbein; Laura Marcu
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-19
Journal Detail:
Title:  Journal of biophotonics     Volume:  4     ISSN:  1864-0648     ISO Abbreviation:  J Biophotonics     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-12-22     Revised Date:  2014-04-14    
Medline Journal Info:
Nlm Unique ID:  101318567     Medline TA:  J Biophotonics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  650-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Endarterectomy, Carotid / methods
Humans
Matrix Metalloproteinase 2 / analysis*,  metabolism
Matrix Metalloproteinase 9 / analysis*,  metabolism
Plaque, Atherosclerotic / metabolism,  pathology*,  surgery
Reproducibility of Results
Sensitivity and Specificity
Spectrometry, Fluorescence / methods*
Time Factors
Grant Support
ID/Acronym/Agency:
R01 HL 67377/HL/NHLBI NIH HHS; R01 HL067377/HL/NHLBI NIH HHS; R01 HL067377-10/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9
Comments/Corrections

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