| A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque. | |
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MedLine Citation:
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PMID: 21770037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Matrix metalloproteinase (MMP)-2 and -9 play important roles in the progression of atherosclerosis. This study aims to determine whether MMP-2 and -9 content in the fibrotic caps of atherosclerotic plaque is correlated with plaque autofluorescence. A time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) system was used to measure the autofluorescence and assess the biochemical composition of human plaques obtained from carotid endarterectomy. Results presented here demonstrate for the first time the ability to characterize the biochemical composition as it relates to MMP-2 and -9 content in the atherosclerotic plaque cap using a label-free imaging technique implemented with a fiberoptic TR-LIFS system. |
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Authors:
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Jennifer E Phipps; Nisa Hatami; Zorina S Galis; J Dennis Baker; Michael C Fishbein; Laura Marcu |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-07-19 |
Journal Detail:
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Title: Journal of biophotonics Volume: 4 ISSN: 1864-0648 ISO Abbreviation: J Biophotonics Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2011-12-22 Revised Date: 2012-09-27 |
Medline Journal Info:
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Nlm Unique ID: 101318567 Medline TA: J Biophotonics Country: Germany |
Other Details:
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Languages: eng Pagination: 650-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Endarterectomy, Carotid
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methods Humans Matrix Metalloproteinase 2 / analysis*, metabolism Matrix Metalloproteinase 9 / analysis*, metabolism Plaque, Atherosclerotic / metabolism, pathology*, surgery Reproducibility of Results Sensitivity and Specificity Spectrometry, Fluorescence / methods* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL 67377/HL/NHLBI NIH HHS; R01 HL067377-10/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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