Document Detail


The fluidity of the serum phospholipids of Fulani pastoralists consuming a high-fat diet.
MedLine Citation:
PMID:  12907134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The semi-nomadic cattle Fulani of northern Nigeria consume a diet rich in saturated fatty acids. Since the quality of an individual's dietary fat can influence the fatty acid composition of their membrane phospholipids (PL), we investigated the effect consumption of relatively large amounts of saturated fat might have on the fatty acid composition and fluidity of the serum PL of the Fulani. We obtained blood serum from 112 Fulani pastoralists (38 males, 74 females) 15-77 years of age and determined the serum fatty acid composition of the total PL fraction of each specimen. Our results indicate that the PL of the Fulani were enriched for saturated fatty acids. The unsaturated/saturated fatty acid ratio was 1.02 for the Fulani PL compared to 1.22-2.08 for seven other reference groups drawn from published reports. In addition, the mean melting point (MMP) of the fatty acyl chains of the serum PL of the Fulani was considerably higher than that of the reference populations (MMP, 30.6 degrees C versus 21.3-26.1 degrees C, respectively). The double bond index (DBI) of the serum PL of the Fulani was much lower than that of the PL of the groups against which comparisons were made (DBI, 0.98 versus 1.24-1.43, respectively). Since serum PL and tissue PL are in dynamic equilibrium, these findings suggest that the tissue PL of the Fulani we studied has considerably less fluid character than those of other populations. Since a variety of membrane functions depend on the fluid property of the acyl chains of their constituent PL, it is conceivable that certain critical membrane-dependent systems, including receptor-ligand interactions, solute transport, enzyme activity and lateral movement of macromolecules, are affected in the Fulani.
Authors:
R H Glew; V A Torres; Y-S Huang; L-T Chuang; D J VanderJagt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  69     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2004-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  245-52     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico, Room 249, BMSB, Albuquerque, NM 87131-5221, USA. rglew@salud.unm.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Dietary Fats / pharmacology*
Fatty Acids / blood
Fatty Acids, Unsaturated / blood
Female
Humans
Male
Membrane Fluidity
Middle Aged
Nigeria / ethnology
Phase Transition
Phospholipids / blood*,  chemistry
Sex Factors
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids

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