| A flow-based synthesis of imatinib: the API of Gleevec. | |
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MedLine Citation:
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PMID: 20309467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates. |
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Authors:
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Mark D Hopkin; Ian R Baxendale; Steven V Ley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-05 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 46 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 2450-2 Citation Subset: IM |
Affiliation:
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Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
/
chemical synthesis*,
chemistry,
therapeutic use Dimethylamines / chemistry Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy Piperazines / chemical synthesis*, chemistry, therapeutic use Pyrimidines / chemical synthesis*, chemistry, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Dimethylamines; 0/Piperazines; 0/Pyrimidines; 110-85-0/piperazine; 124-40-3/dimethylamine; 152459-95-5/imatinib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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