Document Detail


On the flexibility of surface structures of tumor cells in vitro.
MedLine Citation:
PMID:  6423516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When HeLa cells are detached from their support by trypsin, trypsin-EDTA, or by mechanical means large zeiotic blebs are formed. After reseeding the cells onto glass these blebs shrink. Those blebs near the support collapse completely to form lobes in the neighborhood of lobopodia. By scanning and transmission electron microscopy we could show the transformation of these zeiotic blebs into true lobopodia. This implies a repair of cell surface structures and components as well as of the subcortical cytoskeleton.
Authors:
N Paweletz; E M Finze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vitro     Volume:  20     ISSN:  0073-5655     ISO Abbreviation:  In Vitro     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-05-18     Completed Date:  1984-05-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0063733     Medline TA:  In Vitro     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Membrane / drug effects,  ultrastructure*
Edetic Acid / pharmacology
Hela Cells / ultrastructure
Humans
Kinetics
Microscopy, Electron
Trypsin / pharmacology
Chemical
Reg. No./Substance:
60-00-4/Edetic Acid; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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