Document Detail


A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes.
MedLine Citation:
PMID:  16118024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50=0.07 microg/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals.
Authors:
Min Soo Shin; Eun Hwa Kang; Young Ik Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antiviral research     Volume:  67     ISSN:  0166-3542     ISO Abbreviation:  Antiviral Res.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Affiliation:
Liver Cell Signal Transduction Laboratory, Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-606, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / pharmacology*
Cell Line
Ellagic Acid / chemistry,  isolation & purification,  pharmacology*
Gene Products, pol / analysis
Hepatitis B Surface Antigens / analysis
Hepatitis B e Antigens / analysis*
Hepatitis B virus / drug effects*,  physiology
Hepatocytes / virology*
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Phyllanthus / chemistry*
Plant Extracts / isolation & purification,  pharmacology*
Virus Replication / drug effects
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Gene Products, pol; 0/Hepatitis B Surface Antigens; 0/Hepatitis B e Antigens; 0/P protein, Hepatitis B virus; 0/Plant Extracts; 476-66-4/Ellagic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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