Document Detail

The fixation probability of beneficial mutations.
MedLine Citation:
PMID:  18664425     Owner:  NLM     Status:  MEDLINE    
The fixation probability, the probability that the frequency of a particular allele in a population will ultimately reach unity, is one of the cornerstones of population genetics. In this review, we give a brief historical overview of mathematical approaches used to estimate the fixation probability of beneficial alleles. We then focus on more recent work that has relaxed some of the key assumptions in these early papers, providing estimates that have wider applicability to both natural and laboratory settings. In the final section, we address the possibility of future work that might bridge the gap between theoretical results to date and results that might realistically be applied to the experimental evolution of microbial populations. Our aim is to highlight the concrete, testable predictions that have arisen from the theoretical literature, with the intention of further motivating the invaluable interplay between theory and experiment.
Z Patwa; L M Wahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  5     ISSN:  1742-5689     ISO Abbreviation:  J R Soc Interface     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-12-16     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  1279-89     Citation Subset:  IM    
Applied Mathematics, University of Western Ontario, Middlesex College 255, London, Ontario, Canada.
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MeSH Terms
Biological Evolution*
Founder Effect
Genetics, Population*
Models, Genetic*
Mutation / genetics*
Population Density
Population Dynamics

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