| The fixation probability of beneficial mutations. | |
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MedLine Citation:
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PMID: 18664425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fixation probability, the probability that the frequency of a particular allele in a population will ultimately reach unity, is one of the cornerstones of population genetics. In this review, we give a brief historical overview of mathematical approaches used to estimate the fixation probability of beneficial alleles. We then focus on more recent work that has relaxed some of the key assumptions in these early papers, providing estimates that have wider applicability to both natural and laboratory settings. In the final section, we address the possibility of future work that might bridge the gap between theoretical results to date and results that might realistically be applied to the experimental evolution of microbial populations. Our aim is to highlight the concrete, testable predictions that have arisen from the theoretical literature, with the intention of further motivating the invaluable interplay between theory and experiment. |
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Authors:
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Z Patwa; L M Wahl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of the Royal Society, Interface / the Royal Society Volume: 5 ISSN: 1742-5689 ISO Abbreviation: J R Soc Interface Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-12-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101217269 Medline TA: J R Soc Interface Country: England |
Other Details:
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Languages: eng Pagination: 1279-89 Citation Subset: IM |
Affiliation:
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Applied Mathematics, University of Western Ontario, Middlesex College 255, London, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles* Evolution* Founder Effect Genetics, Population* Models, Genetic* Mutation / genetics* Population Density Population Dynamics |
| Comments/Corrections | |
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