Document Detail


A five year experience of the use of factor IX type DE(I) concentrate for the treatment of Christmas disease of Oxford.
MedLine Citation:
PMID:  1201227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A survey is presented of the use of the Oxford type DE(I) II-IX-X concentrate in the treatment of Christmas disease in Oxford from January 1970 to September 1974. 72 different patients were treated with a total of 2436 bottles of this concentrate from 143 different batches (each bottle containing 800-1000 units of factor IX). Although most doses were given for the treatment of minor haemorrhages into joints and muscles, 717 bottles of concentrate were used to treat 11 patients who underwent 14 major surgical operations. No episode of intravascular clotting or pulmonary embolism was seen in any patient receiving the concentrate. A detailed study of the plasma levels of factor V, VIII, total progressive antithrombin, platelets and fibrinogen degradation products was carried out before and after transfusion of type DE(I) concentrate in 14 patients. No significant alteration in those factors was found after the transfusion.
Authors:
J L Lane; C R Rizza; T J Snape
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  30     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1976-03-01     Completed Date:  1976-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antithrombins / blood
Disseminated Intravascular Coagulation / epidemiology
England
Factor IX / administration & dosage,  therapeutic use*
Hemophilia B / therapy*
Humans
Postoperative Complications / epidemiology
Prothrombin / analysis
Time Factors
Chemical
Reg. No./Substance:
0/Antithrombins; 9001-26-7/Prothrombin; 9001-28-9/Factor IX

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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