Document Detail


A five-amino-acid peptide blocks Met- and Ron-dependent cell migration.
MedLine Citation:
PMID:  16024611     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH in human. Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration.
Authors:
Alexandra Matzke; Peter Herrlich; Helmut Ponta; Véronique Orian-Rousseau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  65     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-09-14     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6105-10     Citation Subset:  IM    
Affiliation:
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Karlsruhe, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antigens, CD44 / genetics,  metabolism*
Cell Movement / physiology*
Glycoproteins / antagonists & inhibitors,  genetics,  metabolism*
HT29 Cells
Humans
Molecular Sequence Data
Peptide Fragments / genetics,  metabolism,  pharmacology*
Proto-Oncogene Proteins / antagonists & inhibitors*,  metabolism
Proto-Oncogene Proteins c-met
Rats
Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*,  metabolism
Receptors, Growth Factor / antagonists & inhibitors*,  metabolism
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Antigens, CD44; 0/CD44v6 antigen; 0/Glycoproteins; 0/Peptide Fragments; 0/Proto-Oncogene Proteins; 0/Receptors, Growth Factor; EC 2.7.1.-/RON protein; EC 2.7.10.1/MET protein, human; EC 2.7.10.1/Proto-Oncogene Proteins c-met; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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