| A five-amino-acid peptide blocks Met- and Ron-dependent cell migration. | |
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MedLine Citation:
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PMID: 16024611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH in human. Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration. |
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Authors:
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Alexandra Matzke; Peter Herrlich; Helmut Ponta; Véronique Orian-Rousseau |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer research Volume: 65 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2005-09-14 Revised Date: 2012-06-04 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 6105-10 Citation Subset: IM |
Affiliation:
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Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Karlsruhe, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antigens, CD44 / genetics, metabolism* Cell Movement / physiology* Glycoproteins / antagonists & inhibitors, genetics, metabolism* HT29 Cells Humans Molecular Sequence Data Peptide Fragments / genetics, metabolism, pharmacology* Proto-Oncogene Proteins / antagonists & inhibitors*, metabolism Proto-Oncogene Proteins c-met Rats Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*, metabolism Receptors, Growth Factor / antagonists & inhibitors*, metabolism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD44; 0/CD44v6 antigen; 0/Glycoproteins; 0/Peptide Fragments; 0/Proto-Oncogene Proteins; 0/Receptors, Growth Factor; EC 2.7.1.-/RON protein; EC 2.7.10.1/MET protein, human; EC 2.7.10.1/Proto-Oncogene Proteins c-met; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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