Document Detail

The fission yeast MO25 protein functions in polar growth and cell separation.
MedLine Citation:
PMID:  16325501     Owner:  NLM     Status:  MEDLINE    
Proteins of the MO25 family are widely conserved but their function has not been characterized in detail. Human MO25 is a cofactor of LKB1, a conserved protein kinase with roles in cell polarity in nematodes, flies and mammalian cells. Furthermore, the budding yeast MO25 homologue, Hym1, is important for cell separation and morphogenesis. We have characterized Pmo25p, the MO25 homologue in the fission yeast Schizosaccharomyces pombe. Pmo25p is an essential protein required for polar growth; in its absence the actin cytoskeleton becomes depolarized and cells adopt a round morphology. In addition, pmo25 mutants are defective in cell separation. Both functions of Pmo25p appear to be mediated by the Orb6p-Mob2p kinase complex. Pmo25p shows no distinct localization during interphase, but it is recruited to one of the two spindle pole bodies during anaphase and to the division site during cytokinesis. The septation initiation network (SIN) regulates the localization of Pmo25p, suggesting that it regulates Pmo25p function during cell division.
Manuel Mendoza; Stefanie Redemann; Damian Brunner
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-03
Journal Detail:
Title:  European journal of cell biology     Volume:  84     ISSN:  0171-9335     ISO Abbreviation:  Eur. J. Cell Biol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-03-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906240     Medline TA:  Eur J Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  915-26     Citation Subset:  IM    
European Molecular Biology Laboratory, Heidelberg, Germany.
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MeSH Terms
Anaphase / physiology
Cell Cycle Proteins / genetics,  physiology*
Cell Division / physiology*
Cell Polarity
Cytokinesis / physiology
Cytoskeleton / physiology
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, cdc / physiology
Interphase / physiology
Microscopy, Fluorescence
Mitotic Spindle Apparatus / metabolism
Protein-Serine-Threonine Kinases / genetics,  physiology
Schizosaccharomyces / cytology*,  physiology
Schizosaccharomyces pombe Proteins / genetics,  physiology*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/MO25 protein, S pombe; 0/Schizosaccharomyces pombe Proteins; EC 2.7.1.-/Orb6 protein, S pombe; EC Kinases

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