Document Detail

A fish-oil-rich diet reduces vascular oxidative stress in apoE(-/-) mice.
MedLine Citation:
PMID:  20528577     Owner:  NLM     Status:  MEDLINE    
Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo. To test this, apoE(-/-) mice were fed a corn oil- or a fish oil (FO)-rich diet for 8, 14 or 20 weeks and parameters related to NO and superoxide (O(2)(.-)) plus markers of lipid peroxidation and protein oxidative damage in the aortic root were evaluated. The FO-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered inducible NOS, p22(phox) expression and O(2)(.-)production after 14 and 20 weeks of diet. Protein lipoxidative damage (including 4-hydroxynonenal) was decreased after a long-term FO-diet. This supports the hypothesis that a FO-rich diet could counteract atherogenic oxidative stress, showing beneficial effects of long-chain (n-3) PUFA.
Kelly Casós; María C Zaragozá; Neven Zarkovic; Kamelija Zarkovic; Luka Andrisic; Manuel Portero-Otín; Daniel Cacabelos; María T Mitjavila
Related Documents :
7918617 - Effects of continuous tube feeding of dietary fat emulsions on eicosanoid production an...
11534547 - Suppression of platelet-activating factor generation and modulation of arachidonate met...
17901087 - A combination of intravenous and dietary docosahexaenoic acid significantly improves ou...
15691017 - Dietary fish oil dose- and time-response effects on cardiac phospholipid fatty acid com...
3531437 - Dietary fatty acid modulation of murine b-cell responsiveness.
7436647 - Temporal fat pad sign during corticosteroid treatment.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  821-9     Citation Subset:  IM    
Department of Physiology, INSA, RETICS, University of Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aldehydes / analysis
Aorta / chemistry,  drug effects,  enzymology
Apolipoproteins E / deficiency*,  genetics
Atherosclerosis / genetics,  prevention & control
Corn Oil / administration & dosage,  pharmacology
Cytochrome b Group / biosynthesis,  genetics
Endothelium, Vascular / drug effects*
Fish Oils / administration & dosage,  pharmacology,  therapeutic use*
Hyperlipoproteinemia Type II / diet therapy*,  genetics,  metabolism
Lipid Peroxidation / drug effects
Mice, Knockout
NADPH Oxidase / biosynthesis,  genetics
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / biosynthesis,  genetics
Nitric Oxide Synthase Type III / biosynthesis,  genetics
Oxidative Stress / drug effects*
Reg. No./Substance:
0/Aldehydes; 0/Apolipoproteins E; 0/Cytochrome b Group; 0/Fish Oils; 10102-43-9/Nitric Oxide; 29343-52-0/4-hydroxy-2-nonenal; 8001-30-7/Corn Oil; 8002-50-4/Menhaden oil; EC Oxide Synthase Type II; EC Oxide Synthase Type III; EC protein, mouse; EC protein, mouse; EC Oxidase; EC protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans.
Next Document:  The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kid...