Document Detail


A fish-oil-rich diet reduces vascular oxidative stress in apoE(-/-) mice.
MedLine Citation:
PMID:  20528577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo. To test this, apoE(-/-) mice were fed a corn oil- or a fish oil (FO)-rich diet for 8, 14 or 20 weeks and parameters related to NO and superoxide (O(2)(.-)) plus markers of lipid peroxidation and protein oxidative damage in the aortic root were evaluated. The FO-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered inducible NOS, p22(phox) expression and O(2)(.-)production after 14 and 20 weeks of diet. Protein lipoxidative damage (including 4-hydroxynonenal) was decreased after a long-term FO-diet. This supports the hypothesis that a FO-rich diet could counteract atherogenic oxidative stress, showing beneficial effects of long-chain (n-3) PUFA.
Authors:
Kelly Casós; María C Zaragozá; Neven Zarkovic; Kamelija Zarkovic; Luka Andrisic; Manuel Portero-Otín; Daniel Cacabelos; María T Mitjavila
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  821-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, INSA, RETICS, University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Aldehydes / analysis
Animals
Aorta / chemistry,  drug effects,  enzymology
Apolipoproteins E / deficiency*,  genetics
Atherosclerosis / genetics,  prevention & control
Corn Oil / administration & dosage,  pharmacology
Cytochrome b Group / biosynthesis,  genetics
Endothelium, Vascular / drug effects*
Fish Oils / administration & dosage,  pharmacology,  therapeutic use*
Hyperlipoproteinemia Type II / diet therapy*,  genetics,  metabolism
Lipid Peroxidation / drug effects
Male
Mice
Mice, Knockout
NADPH Oxidase / biosynthesis,  genetics
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / biosynthesis,  genetics
Nitric Oxide Synthase Type III / biosynthesis,  genetics
Oxidative Stress / drug effects*
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Apolipoproteins E; 0/Cytochrome b Group; 0/Fish Oils; 10102-43-9/Nitric Oxide; 29343-52-0/4-hydroxy-2-nonenal; 8001-30-7/Corn Oil; 8002-50-4/Menhaden oil; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos2 protein, mouse; EC 1.14.13.39/Nos3 protein, mouse; EC 1.6.3.1/NADPH Oxidase; EC 1.6.3.1/p22(phox) protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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