Document Detail

The first step to understanding valve failure: an overview of pathology.
MedLine Citation:
PMID:  1389279     Owner:  NLM     Status:  MEDLINE    
The most frequent valve-related complications are thromboembolic problems (including anticoagulant-related hemorrhage), infective endocarditis, paravalvular leak, intrinsic degradative dysfunction, and extrinsic interference with function, including tissue overgrowth. Tissue overgrowth, endocarditis, and paravalvular leak are largely prosthesis-independent. Thrombosis, the major cause of mechanical valve dysfunction, is infrequent with bioprostheses; in contrast, the overwhelming cause of bioprosthetic valve failure is primary tissue degeneration.
F J Schoen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  6 Suppl 1     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-28     Completed Date:  1992-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S50-3     Citation Subset:  IM    
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
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MeSH Terms
Bioprosthesis / classification,  standards*
Heart Valve Prosthesis / classification,  standards*
Models, Cardiovascular
Postoperative Complications / epidemiology,  etiology*,  physiopathology
Prosthesis Design / standards
Prosthesis Failure*
Stress, Mechanical
Thromboembolism / epidemiology*,  physiopathology
Transplantation, Homologous / standards

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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