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A first principles calculation of the oxygen uptake in the human pulmonary acinus at maximal exercise.
MedLine Citation:
PMID:  23201099     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It has recently been shown that the acinus can have a reduced efficiency due to a "screening effect" governed by the ratio of oxygen diffusivity to membrane permeability, the gas flow velocity, as well as the size and configuration of the acinus. We present here a top to bottom calculation of the functioning of a machine acinus at exercise that takes this screening effect into account. It shows that, given the geometry and the breathing dynamics of real acini, respiration can be correlated to a single equivalent parameter that we call the integrative permeability. In particular we find that both [Formula: see text] and [Formula: see text] depend on this permeability in a non-linear manner. Numerical solutions of dynamic convection-diffusion equations indicate that only a narrow range of permeability values is compatible with the experimental measurements of [Formula: see text] and [Formula: see text] . These permeability values are significantly smaller than those found in the literature. In a second step, we present a new type of evaluation of the diffusive permeability, yielding values compatible with the top to bottom approach, but smaller than the usual morphometric value.
Authors:
A Foucquier; M Filoche; A A Moreira; J S Andrade Jr; G Arbia; B Sapoval
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-27
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Physique de la Matière Condensée, CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
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