Document Detail

The first oral rotavirus vaccine, 1998-1999: estimates of uptake from the National Immunization Survey.
MedLine Citation:
PMID:  12690067     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: On August 31, 1998, the rhesus-human reassortant rotavirus vaccine (RRV-TV) was licensed for use in the U.S. During the next nine months, 15 cases of intussusception were reported among infants who received the vaccine. Case-control and cohort studies showed a significantly increased risk of developing intussusception within one week of receiving the vaccine; subsequent ecologic studies did not. In this study, the authors used data on RRV-TV vaccination rates from the National Immunization Survey (NIS) to estimate state and national RRV-TV uptake rates and factors associated with receiving RRV-TV. These estimates are a key component in evaluating published ecologic studies designed to investigate the relationship between receipt of the vaccine and intussusception. METHODS: The authors analyzed NIS data for children ages 19 to 35 months who were eligible to receive RRV-TV between September 1998 and July 1999. The authors estimated vaccine coverage and the number of doses administered by state, NIS sampling quarter, and birth cohort, and analyzed demographic and socioeconomic variables to evaluate their relationship with receiving RRV-TV. RESULTS: It was estimated that approximately 1 million doses of RRV-TV were administered to 504,585 (+/-61,854) children, 13.4% (+/-1.6%) of children who were eligible. The estimated number of doses administered and the vaccination coverage rate varied greatly from state to state. Children living in households with higher socioeconomic conditions were more likely to receive the vaccine. CONCLUSION: Ecologic studies had a limited ability to detect a significant increase in the population incidence rate of intussusception that could be attributed to RRV-TV because populations in these studies consisted primarily of children who did not receive the vaccine. The example from RRV-TV demonstrates some of the challenges of assessing the magnitude of the association between a vaccine and an uncommon or rare adverse event.
Philip J Smith; Ben Schwartz; Ali Mokdad; Alan B Bloch; Mary McCauley; Trudy V Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Public health reports (Washington, D.C. : 1974)     Volume:  118     ISSN:  0033-3549     ISO Abbreviation:  Public Health Rep     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-04-22     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  9716844     Medline TA:  Public Health Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-43     Citation Subset:  AIM; IM    
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
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MeSH Terms
Administration, Oral
Child, Preschool
Cohort Studies
Health Care Surveys
Immunization Programs / utilization*
Intussusception / epidemiology,  etiology*
Population Surveillance
Risk Assessment
Risk Factors
Rotavirus Infections / prevention & control*
Rotavirus Vaccines / administration & dosage,  adverse effects*,  supply & distribution
United States / epidemiology
Vaccines, Attenuated / adverse effects
Reg. No./Substance:
0/Rotavirus Vaccines; 0/Vaccines, Attenuated; 0/rhesus rotavirus vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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