| The first luminal loop confers insulin responsiveness to the glucose transporter 4. | |
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MedLine Citation:
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PMID: 22262463 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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GLUT4 is the major glucose transporter which is regulated by insulin and is alone responsible for the effect of insulin on post-prandial blood glucose clearance. However, the nature of the insulin sensitivity of GLUT4 remains unknown. Here, we have replaced the first luminal loop of cellugyrin, the four-transmembrane protein that does not respond to insulin, with that of GLUT4. The chimera protein is targeted to the intracellular insulin-responsive vesicles and is translocated to the plasma membrane upon insulin stimulation. The faithful targeting of the chimera depends on the expression of the sorting receptor sortilin, that interacts with the unique amino acid residues in the first luminal loop of GLUT4. Thus, the first luminal loop may confer insulin responsiveness to the GLUT4 molecule. |
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Authors:
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Juyoun Kim; Konstantin V Kandror |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Molecular biology of the cell Volume: - ISSN: 1939-4586 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201390 Medline TA: Mol Biol Cell Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Boston University School of Medicine, Boston, MA 02118. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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