Document Detail

The first case history of multiple sclerosis: Augustus d'Est? (1794-1848).
MedLine Citation:
PMID:  19838623     Owner:  NLM     Status:  MEDLINE    
The personal diary of Sir Augustus d'Est?, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease. Charcot coined the term scl?rose en plaques 20 years after the death of this patient in 1848. The onset of this man's MS seems to have been in 1822 with bilateral optic neuritis, the disease gradually developing in the classic manner with bouts derived from different loci in the central nervous system and eventually a secondary progressive form with paraparesis, sphincter incontinence, urinary problems and impotence. In 1941, Firth highlighted the case of Augustus d'Est? and later wrote a description of the pathology including a discussion on the aetiology of MS. No previous medical records have given such a characteristic picture of MS as this.
Anne-Marie Landtblom; Patrik Fazio; Sten Fredrikson; Enrico Granieri
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits     Date:  2009-10-17
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  31     ISSN:  1590-3478     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Division of Neurology, Link?ping University Hospital, 581 85, Link?ping, Sweden.
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MeSH Terms
Disease Progression
Famous Persons*
History, 18th Century
History, 19th Century
Medical Records
Multiple Sclerosis / classification,  history*,  pathology
Risk Factors
Personal Name Subject
Personal Name Subject:
Augustus d'Est?

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