Document Detail


The fine structure of the dopaminergic innervation of area 10 of macaque prefrontal cortex.
MedLine Citation:
PMID:  23331617     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In common with other areas of the prefrontal cortex, activity in frontopolar area 10 is probably modulated by dopamine. We studied the dopaminergic innervation of monkey prefrontal area 10 by immunostaining with tyrosine hydroxylase (TH) antibodies. TH-positive axons in layer 3 were examined by electron microscopy of series of ultrathin sections. TH-positive boutons containing vesicles were sparse (2 × 10(-4) per μm(3) ) and the majority (94%, n = 52) had no identifiable synaptic specialization, which supports the hypothesis that dopamine is released non-synaptically and raises the question of whether the local microenvironment surrounding the boutons is special. Compared with unlabelled boutons TH-positive boutons had a higher proportion of their perimeter in contact with dendritic shafts and were more often in continuous contact with pairs of pre- and postsynaptic structures. However, this may result from exclusion from sites preferred by glutamatergic and GABAergic synapses as the density of all synapses in the closer vicinity was no different from any randomly selected site in the neuropil. This quantitative ultrastructural study presents basic features of the dopaminergic innervation in prefrontal area 10 and provides a more detailed understanding of the structural basis of dopamine signalling in the cortex.
Authors:
Kevan A C Martin; Isabelle A Spühler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  The European journal of neuroscience     Volume:  -     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Affiliation:
Institute of Neuroinformatics, University of Zürich and ETH Zürich, Winterthurerstr.190, 8057, Zürich, Switzerland.
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