| The final outcome of primary infrainguinal percutaneous transluminal angioplasty in 100 consecutive patients with chronic critical limb ischemia. | |
| | |
MedLine Citation:
|
PMID: 11997353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: This study was performed to determine final outcomes in patients treated with infrainguinal percutaneous transluminal angioplasty (PTA) for chronic critical limb ischemia (CLI). MATERIALS AND METHODS: The study population consisted of 100 consecutive patients (mean age, 72 y; range, 38-90 y; 40 men and 60 women) with 116 treated limbs. CLI was defined as rest pain or ischemic tissue defect combined with an ankle systolic pressure < or = 50 mm Hg. Indication for treatment was rest pain in 23 limbs (20%), ischemic ulcer in 50 (43%), and gangrene in 43 (37%). All patients were followed until they had met the study endpoints: major amputation or death. The mean follow-up period was 38 months (1-119 mo). Limb salvage, survival, and life with limb rates were determined along with their determinants. RESULTS: On average, 1.9 invasive procedures were required during the lifespan of a critically ischemic limb, including primary PTA and 32 repeat PTA procedures, 11 surgical revascularizations, and 51 amputations. The major amputation rate was 32% (n = 37). Limb salvage for endovascular treatments at 3, 5, and 8 years was 65%, 60%, and 60%, respectively (SE of estimate [SEE] <or = 0.06), and the corresponding life with limb rates were 29%, 18%, and 6% (SEE < or = 0.05). A greater number of diseased vessels in the treated limb was associated with poorer limb salvage (P =.004). Survival rates were 41%, 26%, and 14% (SEE < or = 0.05) at 3, 5, and 10 years. The 10-year survival rate was markedly poorer than that in the age- and sex-matched control population. Coronary artery disease (P =.001) and poor peripheral runoff (P =.02) were associated with decreased survival. CONCLUSIONS: Infrainguinal PTA in patients with CLI results in acceptable limb salvage with a low number of additional revascularization treatments, but patient survival is poor. |
| | |
Authors:
|
Tiia Jämsén; Hannu Manninen; Harri Tulla; Pekka Matsi |
Related Documents
:
|
12143943 - Limb salvage instead of amputation in 10 cases of nonreconstructible "end-point ischemi... 18755513 - Vibrio necrotizing soft-tissue infection of the upper extremity: factors predictive of ... 8013813 - Laparoscopic hill repair. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of vascular and interventional radiology : JVIR Volume: 13 ISSN: 1051-0443 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-05-08 Completed Date: 2002-06-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 455-63 Citation Subset: IM |
Affiliation:
|
Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, FIN-70200 Kuopio, Finland. tiia.jamsen@kuh.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Angioplasty, Balloon* / methods Chronic Disease Coronary Artery Disease / complications, mortality, therapy Critical Illness Extremities / blood supply* Female Follow-Up Studies Hemodynamics / physiology Humans Inguinal Canal / surgery Ischemia / complications, mortality, surgery* Limb Salvage Male Middle Aged Postoperative Complications / etiology, mortality, surgery Prospective Studies Reoperation Survival Analysis Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: rVista for comparative sequence-based discovery of functional transcription factor binding sites.
Next Document: Endovascular placement of a nitinol-ePTFE stent-graft for abdominal aortic aneurysms: initial and mi...