| The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina. | |
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MedLine Citation:
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PMID: 16364654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The molecular mechanism underlying vertebrate retinal development is not well understood. To examine whether neurogenin2 (ngn2) expression determines cell fate in the retina, we mapped the final fates of cells that once expressed ngn2, using the conditional, binary CreER -LacZ system. We found LacZ+ cells in all 3 nuclear layers of the mouse retina and including all major types of neurons: photoreceptors, horizontal, bipolar, amacrine, and ganglion cells. The distribution of LacZ+ cells among the 3 nuclear layers closely resembled a theoretical distribution of total retinal cells. The temporal window in which each cell type was marked appeared nonrandom, and was similar to its birthdate and birth sequence. These data indicate that cells expressing ngn2 at some point in their life histories may later differentiate into a variety of cell types. |
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Authors:
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Wenxin Ma; Shu-Zhen Wang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-12-20 |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 31 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-13 Completed Date: 2006-05-22 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 463-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Alabama at Birmingham, 700 South 18th Street, Birmingham, AL 35294-0009, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amacrine Cells
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cytology,
metabolism Animals Basic Helix-Loop-Helix Transcription Factors / biosynthesis*, genetics Cell Differentiation / physiology* Cell Lineage / physiology* Cell Proliferation Female Gene Expression Regulation, Developmental / physiology Genes, Reporter / genetics Lac Operon / genetics Male Mice Mice, Transgenic Nerve Tissue Proteins / biosynthesis*, genetics Neurons / cytology, metabolism* Photoreceptor Cells, Vertebrate / cytology, metabolism Retina / cytology, embryology*, metabolism Retinal Bipolar Cells / cytology, metabolism Retinal Ganglion Cells / cytology, metabolism Stem Cells / cytology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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EY11640/EY/NEI NIH HHS; R01 EY011640/EY/NEI NIH HHS; R01 EY011640-07/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors; 0/Nerve Tissue Proteins; 0/Neurog2 protein, mouse |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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