Document Detail

The fifth nonlethal case of primary amoebic meningoencephalitis.
MedLine Citation:
PMID:  2056258     Owner:  NLM     Status:  MEDLINE    
The fifth nonlethal case of primary amoebic meningoencephalitis was reported. He was a 61-year-old gardener from northeast Thailand who had an abrupt onset of high fever, headache and stupor. Lumbar puncture showed numerous naegleria in the cerebrospinal fluid. The combination of 0.5 mg/kg/day of intravenous amphotericin B for 14 days, oral rifampicin and oral ketoconazole for 1 month cured the patient with no recurrence after one year of follow-up. The authors emphasise the regimen of low dose amphotericin B for a prolonged period instead of a high dose over a short period.
N Poungvarin; P Jariya
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  74     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-29     Completed Date:  1991-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Amebiasis / cerebrospinal fluid,  drug therapy*,  mortality
Amphotericin B / administration & dosage,  therapeutic use*
Meningoencephalitis / cerebrospinal fluid,  drug therapy*,  mortality
Middle Aged
Survival Rate
Thailand / epidemiology
Reg. No./Substance:
1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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