| The fifteen years of discoveries that shaped molecular electrophysiology: time for appraisal. | |
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MedLine Citation:
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PMID: 20724724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article serves as an introductory overview to a thematic review series that will present the latest advancements in the field of inherited arrhythmias. This area of cardiac electrophysiology started approximately 15 years ago thanks to the contribution of Mark Keating and coworkers, who discovered the molecular basis of long QT syndrome. The field rapidly expanded when clinicians, molecular biologists, geneticists, and cellular electrophysiologists, who undertook an impressive collaborative effort to clarify the genetic basis of "cardiac channelopathies." As a result of this hard work, the paradigms for diagnosis and management of patients with inherited arrhythmogenic diseases were substantially modified, demonstrating once more the value of "translational research." As more and more genes have been implicated in the genesis of inherited arrhythmias, we keep broadening our understanding of the complexity of ion channels and their multifaceted regulatory processes. Despite the fact that several discoveries have already been made, the field is facing new challenges that are attracting young investigators who share with the pioneers the ambitious goal of finding new therapies and even a cure for these conditions. |
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Authors:
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Silvia G Priori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Circulation research Volume: 107 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-09-16 Revised Date: 2011-11-24 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
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Division of Cardiology and Molecular Cardiology, Fondazione Salvatore Maugeri, Via S Maugeri 10/10 degrees, 27100 Pavia, Italy. silvia.priori@nyumc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / genetics, physiopathology Electrophysiological Phenomena / genetics*, physiology Genetic Testing / methods*, trends* Humans Long QT Syndrome / genetics*, physiopathology* Mutation / genetics |
| Grant Support | |
ID/Acronym/Agency:
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GGP06007//Telethon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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