| A few good responses: which mechanical effects of IOP on the ONH to study? | |
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MedLine Citation:
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PMID: 22570343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The biomechanical effects of IOP on the optic nerve head (ONH) are believed to play a role in glaucomatous neuropathy. There is, however, no consensus on which effects of IOP should be prioritized for investigation. Our goal was to identify a small set of variables capturing the majority of the effects of acute IOP on the ONH. METHODS: We produced 4646 finite element models of the human ONH representing a wide range of tissue anatomies and mechanical properties. The effects of IOP were quantified through a set of 25 responses including stress, strain, and geometric deformation of the lamina cribrosa (LC) and peripapillary sclera. The correlations between the responses were analyzed and principal component analysis (PCA) was used to identify uncorrelated variables capturing the largest possible variance in the responses. RESULTS: The responses formed groups with strong correlations. The top five principal components (PCs) accounted for 72.8%, 13.0%, 7.1%, 3.1%, and 2.0% of the variance, respectively. CONCLUSIONS: Few PCs capture the majority of the mechanical effects of acute changes in IOP on the ONH, which previously required 25 measures. The PCs represented four key effects of IOP: lateral deformation associated with canal expansion (PC1), anterior-posterior deformation of the LC and the forces through it determined by either the mechanical properties of the LC (PC2) or of the neural tissue (PC4), rotation of the peripapillary sclera (PC5), and forces through the peripapillary sclera (PC3). A small set of uncorrelated variables will simplify describing and understanding the effects of IOP on the ONH. |
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Authors:
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Ian A Sigal; Jonathan L Grimm |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-06-28 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 53 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-29 Completed Date: 2012-09-18 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 4270-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA. sigalia@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Computer Simulation* Finite Element Analysis Humans Intraocular Pressure / physiology* Models, Biological* Optic Disk / physiology* Optic Nerve Diseases / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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P30EY008098/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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