Document Detail


The fetus as a patient. Surgical considerations.
MedLine Citation:
PMID:  2009009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnosis and treatment of human fetal defects has evolved rapidly over the past decade due to improved fetal imaging techniques and better understanding of fetal pathophysiology derived from animal models. The detection of a fetal anomaly may now lead to a change in the timing of delivery, a change in the mode of delivery, or prenatal treatment. Because most therapeutic maneuvers involve some risk to the fetus and mother, there must be a reasonable expectation that the procedure is feasible, safe, and effective before it can be attempted in humans. This requires reliable information about the pathophysiology and natural history of the disease process, the efficacy of fetal surgical intervention in ameliorating the disease, and the feasibility and safety of the proposed intervention. This paper focuses on the rationale and initial clinical experience with fetal surgery for a variety of life-threatening fetal anatomic defects.
Authors:
M R Harrison; N S Adzick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  213     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-02     Completed Date:  1991-05-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-91; discussion 277-8     Citation Subset:  AIM; IM    
Affiliation:
Fetal Treatment Program, University of California, San Francisco 94143-0570.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Chylothorax / surgery
Disease Models, Animal
Female
Fetal Diseases / physiopathology,  surgery*
Heart Defects, Congenital / surgery
Hernia, Diaphragmatic / congenital,  surgery
Humans
Hydronephrosis / congenital,  physiopathology,  surgery
Kidney / embryology,  physiopathology
Neoplasms / surgery
Pregnancy
Pregnancy Outcome
Prenatal Diagnosis
Prognosis
Sheep
Grant Support
ID/Acronym/Agency:
HD25505/HD/NICHD NIH HHS; HL39875/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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