Document Detail

The fetus as an allograft: a longitudinal study of normal human pregnancies studied with mixed lymphocyte cultures between mother-father and mother-child.
MedLine Citation:
PMID:  9537059     Owner:  NLM     Status:  MEDLINE    
A longitudinal investigation of the mixed lymphocyte culture (MLC) response during pregnancy between mother and father, between mother and child, and between the mother and an indifferent lymphocyte pool has been carried out, using starting values before pregnancy and a cryobiological freezing system that allows in vitro playback of the immunological course of pregnancy. Lymphocyte and serum samples from twenty-two pregnant women taken before and during pregnancy, at delivery, and after delivery were used. The study shows that the mother reacts during the course of pregnancy with an increasing MLC response to the father, which is replaced at delivery by a decrease in response and a subsequent increase after delivery. It is also shown that the mother reacts to the child in a similar manner at about half the level of reaction to the father. The mother also reacts similarly to a pool of indifferent lymphocytes. The MLC reactions mentioned are affected by both non-pregnant and pregnant serum, leading to a moderation of the MLC reaction in relation to that carried out in neutral AB serum. In addition, there seems to be cooperation between cellular and humoral factors, since the MLC reaction to the child carried out in relevant autologous serum seems to show a decreasing response during the course of pregnancy, in accordance with increasing tolerance of the fetal allograft.
S A Birkeland; K Kristoffersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  11     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1980  
Date Detail:
Created Date:  1998-04-30     Completed Date:  1998-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-9     Citation Subset:  IM    
Tissue Culture Laboratory, Institute of Pathology, Odense University Hospital, Denmark.
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MeSH Terms
Fetus / immunology*
Gestational Age
Infant, Newborn
Longitudinal Studies
Lymphocyte Culture Test, Mixed
Maternal-Fetal Exchange
Pregnancy / immunology*
Time Factors

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