Document Detail


The feto-placental unit stimulates the pregnancy-associated increase in maternal bone metabolism.
MedLine Citation:
PMID:  10920113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to investigate role of the feto-placental unit in the pregnancy-induced increase in maternal bone metabolism. To achieve this, circulating concentrations of carboxy terminal pro-peptide of type I pro-collagen (PICP, a marker of bone formation) and cross-linked carboxy terminal telopeptide of type I collagen (ICTP, a marker of bone resorption) were measured in three groups of pregnant women. Group 1 comprised 12 women with singleton pregnancies; group 2, nine women with twin pregnancies; and group 3, 19 women with multifetal pregnancies (> or =3 fetuses) before and after selective fetal reduction to twin pregnancies. Blood samples were obtained at 10-12 weeks gestation (groups 1-3, pre-fetal reduction in group 3) and 4 weeks and 8 weeks later (groups 2 and 3). Before fetal reduction there was a significant correlation between the number of fetuses and the concentrations of both PICP and ICTP (r = 0.503 and P = 0.001 and r = 0.573 and P < 0.001 respectively). The circulating concentrations of PICP and ICTP were significantly higher in the pre-reduction multifetal pregnancies than in the twin pregnancies (P < 0.001 and P = 0.0013 respectively). The circulating concentrations of ICTP in multifetal pregnancies fell by 4 weeks after fetal reduction to those observed in control twins. Concentrations of PICP were unaltered after fetal reduction. Higher order multiple pregnancies had the greatest decline in ICTP concentrations. These data suggest that the increased bone turnover observed in the multifetal pregnancies is due to a factor derived from the feto-placental unit and that this factor acts primarily to stimulate bone resorption.
Authors:
O Ogueh; G Khastgir; A Abbas; J Jones; K H Nicolaides; J W Studd; J Alaghband-Zadeh; M R Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-06     Completed Date:  2000-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1834-7     Citation Subset:  IM    
Affiliation:
Section of Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers
Bone and Bones / metabolism*
Collagen / blood
Collagen Type I
Extraembryonic Membranes / metabolism
Female
Humans
Peptide Fragments / blood
Peptides / blood
Placenta / metabolism*
Pregnancy
Pregnancy Reduction, Multifetal
Pregnancy, Multiple / metabolism*
Procollagen / blood
Regression Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/collagen type I trimeric cross-linked peptide; 0/procollagen type I carboxy terminal peptide; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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