Document Detail

The fetal safety of thiopurines for the treatment of inflammatory bowel disease in pregnancy.
MedLine Citation:
PMID:  23259868     Owner:  NLM     Status:  In-Data-Review    
Maintaining remission of inflammatory bowel disease (IBD) during pregnancy is critical for positive pregnancy outcomes. Conflicting data exist regarding the association between thiopurine use for IBD treatment in pregnancy and adverse pregnancy outcomes and this meta-analysis aims to clarify this association. A meta-analysis was performed of all original human studies reporting outcomes in pregnancy in patients receiving thiopurines. Nine studies satisfied the inclusion criteria and a total of 494 patients with IBD and 2,782 IBD controls were reported. When compared with healthy women, those receiving thiopurines had an increased risk for congenital malformations (RR 1.45; 95% CI 1.07-1.96; p = 0.02); however, when compared with IBD controls, there was no increased risk (RR 1.37; 95% CI 0.92-2.05; p = 0.1). These data provide support for thiopurines having a minimal risk, if any, to the fetus.
J R Hutson; J N Matlow; M E Moretti; G Koren
Related Documents :
8262678 - Antenatal risk factors for malignant brain tumours in new south wales children.
15512548 - Low back pain, smoking and employment during pregnancy and after delivery - a 3-month f...
23468098 - Sperm selection using magnetic activated cell sorting (macs) in assisted reproduction: ...
12742608 - Pregnant smokers who quit, pregnant smokers who don't: does history of problem behavior...
24771918 - Neonatal transfer rate and mode of delivery from 37th week of gestation in a german per...
17536758 - Maternal early second trimester pregnancy weight in relation to birth outcome among ben...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  33     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dissolved Nitrous Oxide Concentrations and Fluxes from the Eutrophic San Joaquin River, California.
Next Document:  Pregnancy with known syndrome of inappropriate antidiuretic hormone.