Document Detail

The fetal hypothalamus and pituitary in the initiation of labour.
MedLine Citation:
PMID:  205396     Owner:  NLM     Status:  MEDLINE    
Evidence is presented for a number of events in the fetal hypothalamic-pituitary axis which may play a key role in the onset of labour: (1) In the sheep fetus a progressive rise in the fetal circulating concentrations of corticotropin in the days preceding delivery; (2) In the human fetus a switch from the production of corticotropin-like fragments (melanotropin and corticotropin-like intermediate lobe peptide) to authentic corticotropin in the last weeks of gestation; there is evidence also for a placental origin of corticotropin; (3) In the human fetus, a release of oxytocin and vasopressin associated with the process of spontaneous labour.
R Chard; R E Silman; L H Rees
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  -     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1977  
Date Detail:
Created Date:  1978-06-28     Completed Date:  1978-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  359-78     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / metabolism
Fetus / metabolism*
Hydrocortisone / metabolism
Hypothalamo-Hypophyseal System / embryology
Hypothalamus / embryology
Labor, Obstetric*
Neurophysins / metabolism
Oxytocin / metabolism
Pituitary Gland, Posterior / embryology*
Pituitary-Adrenal System / embryology*
Vasopressins / metabolism
Reg. No./Substance:
0/Neurophysins; 11000-17-2/Vasopressins; 50-23-7/Hydrocortisone; 50-56-6/Oxytocin; 9002-60-2/Adrenocorticotropic Hormone

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