Document Detail


The fetal frontomaxillary facial angle in normal and trisomy 21 ultrasounds at 11-13(+6) weeks of gestation: findings among the ethnic Chinese compared with Caucasian.
MedLine Citation:
PMID:  23637079     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this research was to compare the fetal frontomaxillary facial (FMF) angle between normal and trisomy 21 fetuses at 11(+0) -13(+6)  weeks gestation in a Chinese population. METHODS: A prospective observational study was performed that included 640 euploid and 45 trisomy 21 singleton pregnancies undergoing first trimester ultrasound screening between 11 and 13(+6)  weeks of gestation. The FMF angle was measured in the midsagittal plane using the standard technique. RESULTS: The fetal mean FMF angle decreased with the increasing crown-rump length (CRL) from 88.6°at a CRL of 45 mm to 78.5° at a CRL of 84 mm (FMF angle = 100.212 - 0.258 × CRL, R(2)  = 0.222, p < 0.001). The overall mean FMF angle in the euploid population was 82.9° ± 4.1° and in trisomy 21 cases, 92.3° ± 5.2°. CONCLUSIONS: Fetal FMF angle is affected by gestational age in a Chinese population, although it remains a significant predictor of fetal trisomy 21. © 2013 John Wiley & Sons, Ltd.
Authors:
Ching Hua Hsiao; Wen Liang Liu; Ran Chou Chen; Bo Jen Cheng; Yin Jiun Tseng; Woei Chyn Chu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-1
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, Taipei, Taiwan, R.O.C; Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, R.O.C.
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