| The fetal ductus arteriosus and its abnormalities--a review. | |
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MedLine Citation:
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PMID: 21087423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ductus arteriosus (DA) is a small vessel with major functional importance for the integrity of the fetal circulation. Technical advances in prenatal diagnostics facilitate appropriate echocardiographic estimation of the ductal flow and its abnormalities. Despite the emerging knowledge of its embryological background and developmental processes during advancing gestation we still have to face unresolved questions regarding the identification and optimal surveillance of fetuses at risk of premature closure of the ductus. Prenatal administration of tocolytics such as indomethacin should be monitored by close Doppler sonographic scans to follow the ductal circulation. Understanding the transcriptional regulation of normal DA development, maturation, and closure of the arterial duct as well as the hemodynamic changes during pregnancy and after delivery may provide additional targets for rational drug design to either close or open the DA, both antenatally and postnatally. |
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Authors:
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Jan Weichert; David R Hartge; Roland Axt-Fliedner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Congenital heart disease Volume: 5 ISSN: 1747-0803 ISO Abbreviation: Congenit Heart Dis Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-11-22 Completed Date: 2011-03-04 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 398-408 Citation Subset: IM |
Affiliation:
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Division of Prenatal Medicine, Ob/Gyn, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures Ductus Arteriosus / abnormalities*, drug effects, physiopathology, surgery, ultrasonography Ductus Arteriosus, Patent / diagnosis, physiopathology, prevention & control Echocardiography, Doppler Female Heart Aneurysm / congenital, diagnosis, physiopathology, therapy Heart Defects, Congenital* / diagnosis, physiopathology, therapy Hemodynamics Humans Ligation Predictive Value of Tests Pregnancy Tocolytic Agents / therapeutic use Treatment Outcome Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Tocolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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