Document Detail

A ferret model of acute multifocal gastrointestinal infarction.
MedLine Citation:
PMID:  1568569     Owner:  NLM     Status:  MEDLINE    
Based on the demonstration of mural granulomatous vasculitis in Crohn's disease, it was hypothesized that this vasculitis may account for the discontinuous pattern of lesions in this condition. Accordingly, the present study investigated the histological changes produced by interruption of the submucosal and mucosal microcirculation in the ferret midgut. Two techniques were used. First, up to 30 adjacent vasa recta were ligated using microsurgical techniques; this produced no evidence of ischemic damage. Second, interruption of the submucosal collateral plexus by the intra-arterial injection of styrene microspheres (27-, 50-, or 90-microns diameter) produced acute intestinal mucosal damage. A combination of 27- and 90-microns spheres resulted in focal mucosal inflammation, necrosis, and ulceration. "Summit" lesions with normal adjacent mucosa were observed 48 hours after embolization, with evidence of regeneration of the mucosa overlying the occluded vessels at 72 hours. This model shows that focal gastrointestinal infarction with normal adjacent mucosa can be produced by acute occlusion of submucosal and mucosal arteries.
M Hudson; C Piasecki; E A Sankey; R Sim; A J Wakefield; L J More; A M Sawyerr; A P Dhillon; R E Pounder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  102     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1591-6     Citation Subset:  AIM; IM    
University Department of Medicine, Royal Free Hospital School of Medicine, London, England.
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MeSH Terms
Acute Disease
Crohn Disease / etiology*
Disease Models, Animal
Infarction / complications*
Intestinal Mucosa / blood supply*
Grant Support
//Wellcome Trust

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