| A ferret model of acute multifocal gastrointestinal infarction. | |
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MedLine Citation:
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PMID: 1568569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on the demonstration of mural granulomatous vasculitis in Crohn's disease, it was hypothesized that this vasculitis may account for the discontinuous pattern of lesions in this condition. Accordingly, the present study investigated the histological changes produced by interruption of the submucosal and mucosal microcirculation in the ferret midgut. Two techniques were used. First, up to 30 adjacent vasa recta were ligated using microsurgical techniques; this produced no evidence of ischemic damage. Second, interruption of the submucosal collateral plexus by the intra-arterial injection of styrene microspheres (27-, 50-, or 90-microns diameter) produced acute intestinal mucosal damage. A combination of 27- and 90-microns spheres resulted in focal mucosal inflammation, necrosis, and ulceration. "Summit" lesions with normal adjacent mucosa were observed 48 hours after embolization, with evidence of regeneration of the mucosa overlying the occluded vessels at 72 hours. This model shows that focal gastrointestinal infarction with normal adjacent mucosa can be produced by acute occlusion of submucosal and mucosal arteries. |
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Authors:
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M Hudson; C Piasecki; E A Sankey; R Sim; A J Wakefield; L J More; A M Sawyerr; A P Dhillon; R E Pounder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 102 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-05-27 Completed Date: 1992-05-27 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1591-6 Citation Subset: AIM; IM |
Affiliation:
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University Department of Medicine, Royal Free Hospital School of Medicine, London, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Crohn Disease / etiology* Disease Models, Animal Ferrets Infarction / complications* Intestinal Mucosa / blood supply* Microspheres |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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