| The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. | |
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MedLine Citation:
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PMID: 20130660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is thought that diets high in dietary fibre are associated with reduced risk for type 2 diabetes, at least in part because the short-chain fatty acids (SCFAs) produced during the colonic fermentation of fibre beneficially influence circulating concentrations of free-fatty acids (FFAs) and gut hormones involved in the regulation of blood glucose and body mass. However, there is a paucity of data showing this sequence of events in humans. Thus, our objective was to determine the effect of the fermentable fibre inulin on postprandial glucose, insulin, SCFA, FFA, and gut hormone responses in healthy subjects. Overnight fasted healthy subjects (n = 12) were studied for 6 h after consuming 400 mL drinks, containing 80 g high-fructose corn syrup (80HFCS), 56 g HFCS (56HFCS), or 56 g HFCS plus 24 g inulin (Inulin), using a randomized, single-blind, crossover design. A standard lunch was served 4 h after the test drink. Glucose and insulin responses after Inulin did not differ significantly from those after 80HFCS or 56HFCS. Serum acetate, propionate, and butyrate were significantly higher after Inulin than after HFCS drinks from 4-6 h. FFAs fell at a similar rate after all 3 test drinks, but were lower after Inulin than after 56HFCS at 4 h (0.40 +/- 0.06 vs. 0.51 +/- 0.06 mmol*L-1; p < 0.05). Compared with 56HFCS, Inulin significantly increased plasma glucagon-like peptide-1 concentrations at 30 min, and reduced ghrelin at 4.5 h and 6 h. The results are consistent with the hypothesis that dietary fibre increases the production of colonic SCFAs, which may reduce type 2 diabetes risk by reducing postprandial FFAs and favorably affecting gut hormones, which regulate food intake. |
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Authors:
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Joshua Tarini; Thomas M S Wolever |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Applied physiology, nutrition, and metabolism = Physiologie appliqu?e, nutrition et m?tabolisme Volume: 35 ISSN: 1715-5312 ISO Abbreviation: Appl Physiol Nutr Metab Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: Canada |
Other Details:
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Languages: eng Pagination: 9-16 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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blood Adult Blood Glucose / drug effects Butyrates / blood Colon / drug effects Cross-Over Studies Dietary Fiber* Fatty Acids, Nonesterified / blood* Fatty Acids, Volatile / blood* Female Fermentation Ghrelin / blood, drug effects* Glucagon-Like Peptide 1 / blood, drug effects Humans Insulin / blood Inulin / blood, pharmacology* Male Postprandial Period / physiology* Propionates / blood Reference Values Single-Blind Method Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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OOP-64648//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Blood Glucose; 0/Butyrates; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Volatile; 0/Ghrelin; 0/Propionates; 11061-68-0/Insulin; 89750-14-1/Glucagon-Like Peptide 1; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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