| The female and the fragile X reviewed. | |
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MedLine Citation:
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PMID: 11480913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nearly 15 years ago, female carriers of the fragile X mental retardation syndrome were noted to have an increased incidence of twin pregnancies. Since then, much evidence has accumulated supporting the notion of ovarian dysfunction in fragile X carriers, in the forms of increased dizygotic twinning and premature ovarian failure. However, despite a decade and a half of research regarding this association, the underlying mechanism remains a mystery. This article reviews the population-based studies that have examined this association and discusses possible reasons for the variations in results. In addition, results from more recent studies on endocrine function in fragile X carriers are discussed. These data, when considered in conjunction with our emerging understanding of the molecular biology of the fragile X gene (FMR1) and its protein product (FMRP), are beginning to elucidate possible mechanisms for the association between fragile X syndrome and ovarian dysfunction. |
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Authors:
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A Kenneson; S T Warren |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in reproductive medicine Volume: 19 ISSN: 1526-8004 ISO Abbreviation: Semin. Reprod. Med. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-08-01 Completed Date: 2001-12-31 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100909394 Medline TA: Semin Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute and Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Fragility
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genetics Female Fragile X Mental Retardation Protein Fragile X Syndrome / complications*, genetics*, metabolism, physiopathology Heterozygote Humans Models, Biological Nerve Tissue Proteins / genetics, metabolism Ovarian Failure, Premature / complications*, genetics*, metabolism, physiopathology RNA-Binding Proteins* Twins / genetics X Chromosome / genetics* |
| Chemical | |
Reg. No./Substance:
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0/FMR1 protein, human; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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