Document Detail


A feedback-controlled dynamic linear actuator to test foot withdrawal thresholds in rat.
MedLine Citation:
PMID:  17368786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a method for evaluating the threshold for cutaneous mechanical sensation in rodents, based on a stimulator that drives a probe against the plantar surface of the foot. The stimulator applies loads that can be either constant or linearly increased. We describe withdrawal responses, including forms of movement that precede foot withdrawals. With constant stimuli, response latency declines in a nonlinear fashion as stimulus magnitude is increased. With ramped stimuli the effect of loading rate is complex, reflecting both the rate of change of the stimulus and the animal's reaction time. We demonstrate the utility of using ramped stimuli in experiments that show that thresholds vary spatially across the foot and experiments that show that intradermal capsaicin injections cause allodynia but not hyperalgesia.
Authors:
P Grigg; D R Robichaud; G M Bove
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-02-16
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  163     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-08-15     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  44-51     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Massachusetts Medical School, 55 Lake Ave., Worcester MA 01655, USA. peter.grigg@umassmed.edu
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Non-Narcotic / pharmacology
Animals
Behavior, Animal
Capsaicin / pharmacology
Feedback / physiology*
Foot / innervation*
Functional Laterality / drug effects,  physiology
Male
Pain / etiology,  physiopathology*
Pain Measurement
Pain Threshold / drug effects,  physiology*
Physical Stimulation
Probability
Rats
Rats, Wistar
Reaction Time / drug effects,  physiology*
Skin / innervation
Time Factors
Grant Support
ID/Acronym/Agency:
AR048925/AR/NIAMS NIH HHS; NS-10873/NS/NINDS NIH HHS; R01 NS010783-33/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 404-86-4/Capsaicin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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