| The febrile responses in rabbits and rats to leucocyte pyrogens of different species. | |
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MedLine Citation:
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PMID: 671345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. We have investigated the effects on body temperature of rats and rabbits of leucocyte pyrogen derived from the blood of rat, rabbit, ox, pig and baboon. 2. In the rabbit intravenous injections (3.5 ml.) of solutions containing leucocyte pyrogen derived from ox, pig and rabbit blood produced fevers with short latencies; no fevers resulted from injections of similar solutions derived from rat or baboon blood. 3. In the rat intraperitoneal injections (2.0 ml.) of solutions containing leucocyte pyrogen derived from ox blood caused a fever, while pig leucocyte pyrogen produced a marked hypothermia. Neither rabbit, baboon, nor rat leucocyte pyrogen had any significant effect on rectal temperature of the rats. 4. Our results show that there is a variability of response in the rat and the rabbit to injection of leucocyte pyrogen of different species; leucocyte pyrogen may be species specific. |
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Authors:
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D Borsook; H Laburn; D Mitchell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 279 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1978 Jun |
Date Detail:
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Created Date: 1978-09-25 Completed Date: 1978-09-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Cattle Leukocytes Papio Pyrogens / pharmacology* Rabbits Rats Species Specificity Swine |
| Chemical | |
Reg. No./Substance:
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0/Pyrogens |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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