Document Detail


A feasibility and safety study of bronchoscopic thermal vapor ablation: a novel emphysema therapy.
MedLine Citation:
PMID:  19932274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study reports the feasibility and safety of novel second-generation bronchoscopic lung volume reduction (LVR) technology, independent of collateral ventilation. DESCRIPTION: Eleven patients with severe heterogeneous emphysema underwent unilateral bronchoscopic application of vapor thermal energy (mean 4.9 cal/g alveolar tissue; range, 3 to 7.5) with bronchial thermal vapor ablation (BTVA) aiming to induce a controlled inflammatory airway and parenchymal response with resultant LVR. EVALUATION: Nine women and 2 men, with a mean age of 61 years, forced expiratory volume in 1 second (FEV(1)) of 0.77 +/- 0.17 L (32% predicted), residual volume (RV) of 4.1 +/- 0.9 L (219% predicted), and gas transfer of 7.8 +/- 2.2 (34% predicted), underwent unilateral upper lobe treatments. Serious adverse events in 5 included probable bacterial pneumonia and exacerbations of airways disease in 2. Although no important FEV(1) or RV changes occurred during 6 months of follow-up, gas transfer improved, 16% to 9.0% +/- 2.1% (38% predicted), the Medical Research Council Dyspnoea Score improved from 2.6 to 2.1, and the St. George Respiratory Questionnaire Total Score improved from 64.4 at baseline to 49.1. CONCLUSIONS: These preliminary data on unilateral BTVA therapy confirm feasibility, an acceptable safety profile, and the potential for efficacy.
Authors:
Gregory I Snell; Peter Hopkins; Glen Westall; Lynda Holsworth; Anne Carle; Trevor J Williams
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  88     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1993-8     Citation Subset:  AIM; IM    
Affiliation:
Alfred Hospital and Monash University, Melbourne, NSW 3004, Australia. g.snell@alfred.org.au
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MeSH Terms
Descriptor/Qualifier:
Ablation Techniques / instrumentation*
Adult
Aged
Aged, 80 and over
Bronchoscopy / methods*
Equipment Design
Feasibility Studies
Female
Follow-Up Studies
Humans
Male
Middle Aged
Pulmonary Emphysema / surgery*
Questionnaires
Steam*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Steam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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