Document Detail

The feasibility and morbidity of distal pancreatectomy in extensive cytoreductive surgery for advanced epithelial ovarian cancer.
MedLine Citation:
PMID:  15480722     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Pancreatic metastasis of ovarian cancer is extremely rare and its therapeutic approach is not well documented. The objective of this study is to evaluate the feasibility and morbidity of pancreatic resection as a component of extensive cytoreductive surgery in epithelial ovarian cancer (EOC) patients with pancreas metastasis. METHODS: Between December 2000 and February 2003, 98 EOC patients were treated with primary cytoreduction. Six (6.12%) of these patients had pancreatic tail metastasis and were operated on using the distal pancreatectomy. RESULTS: Preoperatively, only 1 (16.7%) of the 6 patients had signs of metastasis to the pancreas on computed tomography (CT). Optimal cytoreduction (absent or < or =1 cm macroscopic residual tumor size) was achieved in all patients. In the early postoperative period, there were 4 patients (66.7%) with complications and no perioperative mortality. In 1 patient (16.7%), glucose intolerance as a late complication of pancreatic resection was detected. All patients received six cycles of platinum-based adjuvant chemotherapy following a cytoreductive operation. Mean follow-up was 27 months (range 9-36), and 3 (50%) patients are still alive at the end of the study period. The two-year survival rate was 66.7%. CONCLUSION: In conclusion, if optimal cytoreduction is foreseen in advanced epithelial ovarian cancer with pancreatic tail metastasis, distal pancreatectomy should be kept in mind. This procedure has acceptable morbidity and seems to be an attribute for survival.
Yusuf Yildirim; Muzaffer Sanci
Publication Detail:
Type:  Journal Article     Date:  2004-10-09
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  272     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2006-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Department of Gynecologic Oncology, SSK (Social Security Agency) Aegean Obstetrics and Gynecology Teaching Hospital, Izmir, Turkey.
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MeSH Terms
Adenocarcinoma / mortality,  secondary,  surgery*
Feasibility Studies
Middle Aged
Ovarian Neoplasms / mortality,  pathology,  surgery*
Pancreatectomy / adverse effects,  methods*,  mortality
Pancreatic Neoplasms / mortality,  secondary,  surgery*
Postoperative Complications / epidemiology
Survival Rate
Tomography, X-Ray Computed

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